nucleolusnuˈkli ə ləs, nyu-; -ˌlaɪ
nucleolus (n)
English Definitions:
nucleolus, nucleole (noun)
a small round body of protein in a cell nucleus; such organelles contain RNA and are involved in protein synthesis
nucleolus (Noun)
A conspicuous, rounded body within the nucleus of a cell.
Nucleolus
The nucleolus is a non-membrane bound structure found in the nucleus of cells. It is composed of proteins and nucleic acids found within the nucleus of eukaryotic cells. Its function is to transcribe ribosomal RNA and assemble it within the cell. The nucleolus ultrastructure can be visualized through an electron microscope, while the organization and dynamics can be studied through fluorescent protein tagging and fluorescent recovery after photobleaching. Antibodies against the PAF49 protein can also be used as a marker for the nucleolus in immunofluorescence experiments. Malfunction of nucleoli can be the cause for several human diseases. It takes up to about 25% of the nuclear volume.
Nucleolus
The nucleolus (, plural: nucleoli ) is the largest structure in the nucleus of eukaryotic cells. It is best known as the site of ribosome biogenesis, which is the synthesis of ribosomes. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to stress. Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies" and the nucleolus is being investigated as a target for cancer chemotherapy.
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