nitroglycerinˌnaɪ trəˈglɪs ər ɪn; -ər ɪn, -əˌrin
nitroglycerin
English Definitions:
nitroglycerin, nitroglycerine, trinitroglycerin, glyceryl trinitrate, Nitrospan, Nitrostat (noun)
a heavy yellow poisonous oily explosive liquid obtained by nitrating glycerol; used in making explosives and medically as a vasodilator (trade names Nitrospan and Nitrostat)
Nitroglycerin
Nitroglycerin, also known as nitroglycerine, trinitroglycerin, trinitroglycerine, or nitro, is more correctly known as glyceryl trinitrate or more formally: 1,2,3-trinitroxypropane. It is a heavy, colorless, oily, explosive liquid most commonly produced by treating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester. Chemically, the substance is an organic nitrate compound rather than a nitro compound, but the traditional name is often retained. Since the 1860s, nitroglycerin has been used as an active ingredient in the manufacture of explosives, mostly dynamite, and as such it is employed in the construction, demolition, and mining industries. Similarly, since the 1880s, it has been used by the military as an active ingredient, and a gelatinizer for nitrocellulose, in some solid propellants, such as Cordite and Ballistite. Nitroglycerin is also a major component in double-based smokeless gunpowders used by reloaders. Combined with nitrocellulose, there are hundreds of combinations used by rifle, pistol, and shotgun reloaders. Nitroglycerin is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. Having been used for over 130 years, nitroglycerin is one of the oldest and most useful drugs for treating and preventing attacks of angina pectoris. Though it was previously known that these effects arise because nitroglycerin is converted to nitric oxide, a potent vasodilator, it was not until 2002 that the enzyme for this conversion was discovered to be mitochondrial aldehyde dehydrogenase. Nitroglycerin comes in forms of tablets, sprays or patches. It has been suggested for other uses also, such as an adjunct therapy in prostate cancer.
Nitroglycerin
Nitroglycerin (NG), (alternative spelling of nitroglycerine) also known as trinitroglycerin (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a dense, colorless, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester. Chemically, the substance is an organic nitrate compound rather than a nitro compound, but the traditional name is retained. Invented in 1847 by Ascanio Sobrero, nitroglycerin has been used ever since as an active ingredient in the manufacture of explosives, namely dynamite, and as such it is employed in the construction, demolition, and mining industries. Since the 1880s, it has been used by militaries as an active ingredient and gelatinizer for nitrocellulose in some solid propellants such as cordite and ballistite. It is a major component in double-based smokeless propellants used by reloaders. Combined with nitrocellulose, hundreds of powder combinations are used by rifle, pistol, and shotgun reloaders. Nitroglycerin has been used for over 130 years in medicine as a potent vasodilator (dilation of the vascular system) to treat heart conditions, such as angina pectoris and chronic heart failure. Though it was previously known that these beneficial effects are due to nitroglycerin being converted to nitric oxide, a potent venodilator, the enzyme for this conversion was only discovered to be mitochondrial aldehyde dehydrogenase (ALDH2) in 2002. Nitroglycerin is available in sublingual tablets, sprays, ointments, and patches.
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"nitroglycerin." Kamus.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.kamus.net/english/nitroglycerin>.
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