thymusˈθaɪ məs
thymus (n)
- plural
- thymuses
English Definitions:
Thymus, genus Thymus (noun)
large genus of Old World mints: thyme
thymus gland, thymus (noun)
a ductless glandular organ at the base of the neck that produces lymphocytes and aids in producing immunity; atrophies with age
thymus (Noun)
A ductless gland, consisting mainly of lymphatic tissue, located behind the top of the breastbone. It is most active during puberty, after which it shrinks in size. It plays an important role in the development of the immune system and produces lymphocytes.
Thymus
The thymus is a specialized organ of the immune system. The thymus "educates" T-lymphocytes, which are critical cells of the adaptive immune system. Each T cell attacks a foreign substance which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different antigen. T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from elsewhere in the body. First T cells undergo "Positive Selection" whereby the cell comes in contact with self-MHC expressed by thymic epithelial cells, those with no interaction are destroyed. Second, the T cell undergoes "Negative Selection" by interacting with thymic dendritic cell whereby T cells with high affinity interaction are eliminated through apoptosis, and those with intermediate affinity survive. The thymus is composed of two identical lobes and is located anatomically in the anterior superior mediastinum, in front of the heart and behind the sternum. Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T-cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin. Developing T-cells are referred to as thymocytes and are of hematopoietic origin. Stromal cells include thymic cortical epithelial cells, thymic medullary epithelial cells, and dendritic cells.
Thymus
The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or T cells mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. The thymus is located in the upper front part of the chest, in the anterior superior mediastinum, behind the sternum, and in front of the heart. It is made up of two lobes, each consisting of a central medulla and an outer cortex, surrounded by a capsule. The thymus is made up of immature T cells called thymocytes, as well as lining cells called epithelial cells which help the thymocytes develop. T cells that successfully develop react appropriately with MHC immune receptors of the body (called positive selection) and not against proteins of the body (called negative selection). The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to decrease in size and activity and the tissue of the thymus is gradually replaced by fatty tissue. Nevertheless, some T cell development continues throughout adult life. Abnormalities of the thymus can result in a decreased number of T cells and autoimmune diseases such as autoimmune polyendocrine syndrome type 1 and myasthenia gravis. These are often associated with cancer of the tissue of the thymus, called thymoma, or tissues arising from immature lymphocytes such as T cells, called lymphoma. Removal of the thymus is called thymectomy. Although the thymus has been identified as a part of the body since the time of the Ancient Greeks, it is only since the 1960s that the function of the thymus in the immune system has become clearer.
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"thymus." Kamus.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.kamus.net/english/thymus>.
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